Tessy Lopez Goerne

Adjunct Professor

5606-3822 ext. 5034
School of Science & Engineering
Tessy Lopez Goerne

Info

Department of Nanomedicine
Universidad Autónoma Metropolitana Xochimilco
Instituto Nacional de Neurología y Neurocirugía "MVS" SSA
Laboratory of Nanotechnology and Nanomedicine

 

Education & Affiliations

B.S., National Metropolitan University of Mexico, 1983
M.S., National Metropolitan University of Mexico, 1986
Ph.D., National Metropolitan University of Mexico, 1989

Biography

My research interests include Medical implants, Controlled Drug release, Chemotherapy, Nanomedicine. Sol-gel Synthesis, Nanostructured materials

My current area of research is focused on the use of ceramic implants, which can be used to encapsulate drugs. These drugs are then released to specific injured tissue. Of particular interest in our laboratory has been to perform extensive studies on the treatment of epilepsy and Parkinson’s disease.

In the case of epilepsy, implantation of these ceramic devices is performed in the temporal lobe of the brain. In the case of Parkinson’s disease, the ceramics implants are inserted in the substantia nigra.

Implantation of these devices is performed using stereotaxic surgery. This mode of drug release is more effective than systemic administration, as passage across the blood brain barrier (BBB) is avoided and therefore, lower drug doses are required. This approach leads to a marked decrease in toxicity.

The use of animal models is extensively used in this research. In the case of the administration of dopamine, a major problem is the stabilization of dopamine through the use of silica. We have found that silica is more effective than titania in the stabilization of dopamine whereas titania appears to be the ceramic of choice in the delivery of valproic acid or phenitoin in the abatement of epilepsy.

Our group has recently been involved in drug release used in the abatement of cancer. In these studies, controlled drug release is applied as a chemotherapic agent as a follow up to tumor removal by surgical means. Nanoparticles, in which the drug is encapsulated, is filtered in to the tumor damaged area following surgical removal. Cis-platinum and platinum 2 analogues are being used in these studies with great success.

Publications

Fractal Analysis of EEG Signals in the Brain of Epileptic Rats, with and without Biocompatible Implanted Neuroreservoirs. T. Lopez, C. L. Martinez-Gonzalez, J. Manjarrez, N. Plascencia, A. S. Balankin. Appl. Mech. And Mat. 15 (2009) 127-136.
Fractal Analysis of Tissue Biocompatible Neuroreservoir.T. López, M. Patiño-Ortiz, A. S. Balankin, R. D. González.  Appl. Mech. And Mat. 15(2009) 121-126.
Kinetics of drug release: phenytoin from sol-gel silica matrices.Alexandra Fidalgo, Tessy M. Lopez, Laura M. Ilharco. J. Sol-gel Science and Technology 49 (2009) 320-328.
Controlled release of phenytoin from nanostructured TiO2 reservoirs.B. E. Heredia-Cervera, S. A. Gonzalez-Azcorra, G. Rodríguez-Gattorno, T. López, E. A. Ortiz, and G. Oskam, Sci. Adv.Mater.1, 63-68 (2009).
Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using C6 Model in Wistar rats. T. López, S. Recillas, P. Guevara, J. Sotelo, M. Alvarez, J. A. Odriozola.Acta Biomaterialia 4(2008) 2037-2044.
Catalytic combustion of soot. Effects of added alkali metals on CaO-MgO physical mixtures. R. Jiménez, X. García, T. López and A. L. Gordon. Fuel Processing Technology. 89 (2008)1160-1168.
Photocatalytic degradation of 2,4-dichlorophenoxyacetic acid using nanocrystalline cryptomelane composite catalysts.M. Alvarez Lemus, T. López, S. Recillas, D.M. Frías, M. Montes, J.J. Delgado, M.A. Centeno, J.A. Odriozola.J. of Molecular Catalysis A: Chemical 281(2008) 107–112.
Study of the photoactivation of TiO2 Degussa P25 in ethanol-methanol suspensions using a piezoelectric sensor. R. Trejo, J. J. Alvarado Gil, T. López, P. Quintana. J. Molecular Catalysis A: Chemical 281 (2008) 113-118.
X-ray diffraction and Raman Scattering Study of NanostructuredZrO2-TiO2 Oxides Prepared by Sol-Gel. T. López, X. Bokhimi, P. Quintana, D. Aguilar, J. M. Coronado, M.E. Manriquez, M. Picquart. Journal Nanoscience and Nanotechnology 8(12)(2008) 6623-9.
Thermal phase stability and catalytic properties of nanostructured TiO2-MgO sol-gel mixed oxides.  T. Lopez, J. Hernandez-Ventura, D. H. Aguilar and P. Quintana. Journal Nanoscience and Nanotechnology 8(12)(2008)6608-17.
Photocatalytic degradation of 2,4-diclorophenoxyacetic acid  over ZrO2, Cu/ZrO2 and Fe/ ZrO2 photocatalysts synthesized by the sol gel method.M. Alvarez, T. Lopez, J. A. Odriozola, R. D. Gonzalez. Journal Nanoscience and Nanotechnology. 8(12)(2008) 6414.
Antibacterial activity of montmorillonites modified with silver.S.M. Magaña, P. Quintana, D.H. Aguilar, J.A. Toledo, Angeles-Chávez, M.A. Cortés, L. León, Y. Freile-Pelegrýn,T. Lopez, R.M. Torres Sanchez. J. Molecular Catalysis 281(2008) 192-199.