Animal models in Biomedical Research 4180/6180
Education & Affiliations
Our lab uses a combination of mouse genetics and in vitro experimental approaches to understand the basic molecular mechanisms of vascular development and disease. A main focus of the lab is to elucidate the molecular pathways associated with the vascular genetic disorder Hereditary Hemorrhagic Telangiectasia (HHT). In particular, we aim to identify TGFb downstream targets that are involved in the formation of arteriovenous malformations (AVMs) that occur in HHT patients. We are also interested in identifying genes with novel roles in vascular biology. Our favorite vascular model is the mouse retina, but we also investigate embryonic and brain vascular development.