Partha Chandra, PhD

Dr. Chandra’s research focuses on elucidating the molecular mechanisms underlying pathophysiological alterations in the brain microvasculature (MVs), which comprises terminal arterioles, capillaries, and venules, in the context of sex differences, aging, and HIV infection. Cerebral small-vessel disease is a major contributor to cognitive impairment, highlighting the critical role of cerebral MVs in maintaining normal brain function. Aging represents an unavoidable biological stressor that progressively impairs brain microvascular function, adversely affecting neuronal health and increasing susceptibility to cognitive decline and dementia. In addition, pronounced sex disparities and the impact of HIV infection are evident in the prevalence and progression of several neurological disorders/diseases.

Circulating extracellular vesicles (EVs) are released and taken up by nearly all cell types and serve as important mediators of intercellular communication. Their cargo, including proteins, RNAs, and other bioactive molecules, can exert either beneficial or detrimental effects on recipient cells. Dr. Chandra’s research team investigates how distinct EV populations, including large EVs, small EVs (exosomes), and exomeres, contribute to pathophysiological alterations in cerebral MVs associated with aging, biological sex, and HIV infection, and how these changes may contribute to neuropathogenesis.