2023
Busschaert, N., García-López, V., Ke, C., McGuirk, C.M., Shimizu, L.S., Gerthoffer, M.C., Bhattacharjee, N. NASC: Bringing Together Supramolecular Chemists from Across North America. Supramol. Chem. (2023). In Press. DOI: 10.1080/10610278.2023.2178724.
Herschede, S.R., Salam, R., Gneid, H., Busschaert, N. Bacterial cytological profiling identifies transmembrane anion transport as the mechanism of action for a urea-based antibiotic. Supramol. Chem. (2023). In Press. DOI: 10.1080/10610278.2023.2178921.
2022
Leigh, J.S., Busschaert, N., Haynes, C.J., Hiscock, J.R., Hutchins, K.M., von Krbek, L.K., McConnell, A.J., Slater, A.G., Smith, D.K. and Draper, E.R. Planning a family. Nat. Rev. Chem., 6, 673–675 (2022). DOI: 10.1038/s41570-022-00427-0
Williams, E.S., Gneid, H., Marshall, S.R., González, M.J., Mandelbaum, J.A., Busschaert, N. A supramolecular host for phosphatidylglycerol (PG) lipids with antibacterial activity. Org. Biomol. Chem., 20, 5958-5966 (2022). DOI: 10.1039/D1OB02298A.
Slater, A., Caltagirone, C., Draper, E., Busschaert, N., Hutchins, K., Leigh, J. Pregnancy in the lab. Nat. Rev. Chem., 6, 163–164 (2022). DOI: 10.1038/s41570-022-00362-0
Leigh, J.S., Hiscock, J.R., Koops, S., McConnell, A.J., Haynes, C.J.E., Caltagirone, C., Kieffer, M., Draper, E.R., Slater, A.G., Hutchins, K.M., Watkins, D., Busschaert, N., von Krbek, L.K.S., Jolliffe, K.A., Hardie, M.J. Managing research throughout COVID-19: Lived experiences of supramolecular chemists. Chem, 8, 299-311 (2022). DOI: 10.1016/j.chempr.2022.01.001
Busschaert, N., Maity, D., Samanta, P.K., English, N.J., Hamilton, A.D. Improving structural stability and anticoagulant activity of a thrombin binding aptamer by aromatic modifications. ChemBioChem, 23, e2021006 (2022). DOI: 10.1002/cbic.202100670
2021
Salam, R., Chowdhury, S.M., Marshall, S.R., Gneid, H. Busschaert, N. Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters, Chem. Commun. 57, 13122-13125 (2021). DOI: 10.1039/D1CC02327F
Herschede, S.R., Gneid, H., Dent, T., Jaeger E.B., Lawson, L., Busschaert, N. Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids. Org. Biomol. Chem., 19, 3838-3843 (2021). DOI: 10.1039/D1OB00263E
2020
Marshall, S.R., Singh, A., Wagner, J.N., Busschaert, N. Enhancing the selectivity of optical sensors using synthetic transmembrane ion transporters. Chem. Commun. 56, 14455-14458 (2020). DOI: 10.1039/D0CC06437H
2019
Li, H., Valkenier, H., Thorne, A.G., Dias, C.M., Cooper, J.A., Kieffer, M., Busschaert, N., Gale, P.A., Sheppard, D.N., Davis, A.P. Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs. Chem. Sci. 10, 9663-9672 2019). DOI: 10.1039/C9SC04242C.
Park, S.-H., Park, S.-H., Howe, E.N.W., Hyun, J.Y., Chen, L.-J., Hwang, I., Vargas-Zuñiga, G., Busschaert, N., Gale, P.A., Sessler, J.L., Shin, I. Determinants of Ion-Transporter Cancer Cell Death. Chem 5, 2079-2098. DOI: 10.1016/j.chempr.2019.05.001.
Zhang, S., Wang, Y., Xie, W., Howe, E.N.W., Busschaert, N., Sauvat, A., Leduc, M., Gomes-da-Silva,L.C., Chen, G., Martins, I., Deng, X., Maiuri, L., Kepp, O., Soussi, T., Gale, P.A., Zamzami, N., Kroemer, G. Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux. Cell Death Dis. 10, 242-252 (2019). DOI: 10.1038/s41419-019-1474-8.
Spooner, M.J., Li, H., Marques, I., Costa, P.M.R., Wu, X., Howe, E.N.W., Busschaert, N., Moore, S.J., Light, M.E., Sheppard, D.N., Félix, V., Gale, P.A. Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport. Chem. Sci. 10, 1976-1985 (2019). DOI: 10.1039/C8SC05155K.
2018
Marques, I., Costa, P.M.R., Miranda, M.Q., Busschaert, N., Howe, E.N.W., Clarke, H.J., Haynes, C.J.E., Kirby, I.K., Rodilla, A.M., Pérez-Tomás, R., Gale, P.A., Félix, V. Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations. Phys. Chem. Chem. Phys. 20, 20796-20811 (2018). DOI: 10.1039/C8CP02576B.
Jowett, L.A., Howe, E.N.W., Wu, X., Busschaert, N., Gale, P.A. New insights into the anion transport selectivity and mechanism of tren-based tris-(thio)ureas. Chem. Eur. J. 24, 10475-10487 (2018). DOI: 10.1002/chem.201801463.
Cheung S., Wu D., Daly H.C., Busschaert N., Morgunova M., Simpson J.C., Scholz D., Gale P.A., O’Shea D.F. Real-time Recording of the Cellular Effects of the Anion Transporter Prodigiosin. Chem 4, 879-895 (2018). DOI: 10.1016/j.chempr.2018.02.009.
2017
Yang Y., Wu X., Busschaert N., Furuta H., Gale P.A. Dissecting the chloride–nitrate anion transport assay. Chem. Commun. 53, 9230-9233 (2017). DOI: 10.1039/C7CC04912A.
Busschaert, N., Park, S.-H., Baek, K.-H., Choi, Y.P., Park, J., Howe, E.N.W., Hiscock, J.R., Karagiannidis, L.E., Marques, I., Félix, V., Namkung, W., Sessler, J.L., Gale, P.A., Shin, I. A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations. Nature Chem. 9, 667-675 (2017). DOI: 10.1038/nchem.2706.
Busschaert, N., Thompson, S., Hamilton, A.D. An a-helical peptidomimetic scaffold for dynamic combinatorial library formation. Chem. Commun. 53, 313-316 (2017). DOI: 10.1039/C6CC07787K.
2016
Howe, E.N.W., Busschaert, N., Wu, X., Berry, S.N., Ho, J., Light, M.E., Czech, D.D., Klein, H.A., Kitchen, J.A., Gale, P.A. pH-regulated nonelectrogenic anion transport by phenylthiosemicarbazones. J. Am. Chem. Soc. 138, 8301-8308 (2016). DOI: 10.1021/jacs.6b04656.
Wu, X., Judd, L.W., Howe, E.N.W., Withecombe, A.M., Soto-Cerrato, V., Li, H., Busschaert, N., Valkenier, H., Pérez-Tomás, R., Sheppard, D.N., Jiang, Y.-B., Davis, A.P., Gale, P.A. Nonprotonophoric electrogenic Cl− transport mediated by valinomycin-like carriers. Chem 1, 127-146 (2016). DOI: 10.1016/j.chempr.2016.04.002.
Share, A.I., Patel, K., Nativi, C., Cho, E.J., Francesconi, O., Busschaert, N., Gale, P.A., Roelens, S., Sessler, J.L. Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Chem. Commun. 52, 7560-7563 (2016). DOI: 10.1039/C6CC03645G.
Knight, N.J., Hernando, E., Haynes, C.J.E., Busschaert, N., Clarke, H.J., Takimoto, K., García-Valverde, M., Frey, J.G., Quesada, R., Gale, P.A. QSAR analysis of substituent effects on tambjamine anion transporters. Chem. Sci. 7, 1600-1608 (2016). DOI: 10.1039/C5SC03932K.
2015
Yamashita, T., Knipe, P.C., Busschaert, N., Thompson, S., Hamilton, A.D. A modular synthesis of conformationally preorganised extended β‐strand peptidomimetics. Chem. Eur. J. 21, 14699-14702 (2015). DOI: 10.1002/chem.201501366.
Busschaert, N., Caltagirone, C., Van Rossom, W., Gale, P.A. Applications of supramolecular anion recognition. Chem. Rev. 115, 8038-8155 (2015). DOI: 10.1021/acs.chemrev.5b00099.
Wu, X., Busschaert, N., Wells, N.J., Jiang, Y.-B., Gale, P.A. Dynamic covalent transport of amino acids across lipid bilayers. J. Am. Chem. Soc. 137, 1476-1484 (2015). DOI: 10.1021/ja510063n.
Berry, S.N., Busschaert, N., Frankling, C.L., Salter, D., Gale, P.A. Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism. Org. Biomol. Chem. 13, 3136-3143 (2015). DOI: 10.1039/C4OB02631D.
Kadam, S.A., Martin, K., Haav, K., Toom, L., Mayeux, C., Pung, A., Gale, P.A., Hiscock, J.R., Brooks, S.J., Kirby, I.L., Busschaert, N., Leito, I. Towards the discrimination of carboxylates by hydrogen‐bond donor anion receptors. Chem. Eur. J. 21, 5145-5160 (2015). DOI: 10.1002/chem.201405858.
Edwards, S.J., Valkenier, H., Busschaert, N., Gale, P.A., Davis, A.P. High‐affinity anion binding by steroidal squaramide receptors. Angew. Chem. Int. Ed. 54, 4675-4679 (2015). DOI: 10.1002/anie.201411805.
Elmes, R.B.P., Busschaert, N., Czech, D.D., Gale, P.A., Jolliffe, K.A. pH switchable anion transport by an oxothiosquaramide. Chem. Commun. 51, 10107-10110 (2015). DOI: 10.1039/C5CC03625A.
2014
Gale, P.A., Busschaert, N., Haynes, C.J.E., Karagiannidis, L.E., Kirby, I.L. Anion receptor chemistry: highlights from 2011 and 2012. Chem. Soc. Rev. 43, 205-241 (2014). DOI: 10.1039/C3CS60316D.
Busschaert, N., Karagiannidis, L.E., Wenzel, M., Haynes, C.J.E., Wells, N.J., Young, P.G., Makuc, D., Plavec, J., Jolliffe, K.A., Gale, P.A. Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport. Chem. Sci. 5, 1118-1127 (2014). DOI: 10.1039/C3SC52006D.
Haynes, C.J.E., Busschaert, N., Kirby, I.L., Herniman, J., Light, M.E., Wells, N.J., Marques, I., Félix, V., Gale, P.A. Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding. Org. Biomol. Chem. 12, 62-72 (2014). DOI: 10.1039/C3OB41522H.
Ko, S.-K., Kim, S.-K., Share, A., Lynch, V.M., Park, J., Namkung, W., Van Rossom, W., Busschaert, N., Gale, P.A., Sessler, J.L., Shin, I. Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells. Nature Chem. 6, 885-892 (2014). DOI: 10.1038/nchem.2021.
Busschaert. N., Jaramillo-Garcia, J., Light, M.E., Herniman, J., Langley, G.J., Gale, P.A. An anion-binding fluorinated alcohol isophthalamide isostere. RSC Adv. 4, 5389-5393 (2014). DOI: 10.1039/C3RA45956J.
Busschaert, N., Elmes, R.B.P., Czech, D.D., Wu, X., Kirby, I.L., Peck, E.M., Hendzel, K.D., Shaw, S.K., Chan, B., Smith, B.D., Joliffe, K.A., Gale, P.A. Thiosquaramides: pH switchable anion transporters. Chem. Sci. 5, 3617-3626 (2014). DOI: 10.1039/C4SC01629G.
Marques, I., Colaço, A.R., Costa, P.J., Busschaert, N., Gale, P.A., Félix, V. Tris-thiourea tripodal-based molecules as chloride transmembrane transporters: insights from molecular dynamics simulations. Soft Matter 10, 3608-3621 (2014). DOI: 10.1039/C3SM52140K.
2013
Busschaert, N., Gale, P.A. Small‐molecule lipid‐bilayer anion transporters for biological applications. Angew. Chem. Int. Ed. 52, 1374-1382 (2013). DOI: 10.1002/anie.201207535.
Busschaert, N., Bradberry, S.J., Wenzel, M., Haynes, C.J.E., Hiscock, J.R., Kirby, I.L., Karagiannidis, L.E., Moore, S.J., Wells, N.J., Herniman, J., Langley, G.J., Horton, P.N., Light, M.E., Marques, I., Costa, P.J., Félix, V., Frey, J.G., Gale, P.A. Towards predictable transmembrane transport: QSAR analysis of anion binding and transport. Chem. Sci. 4, 3036-3045 (2013). DOI: 10.1039/C3SC51023A.
Hiscock, J.R., Piana, F., Sambrook, M.R., Wells, N.J., Clark, A.J., Vincent, J.C., Busschaert, N., Brown, R.C.D., Gale, P.A. Detection of nerve agent via perturbation of supramolecular gel formation. Chem. Commun. 49, 9119-9121 (2013). DOI: 10.1039/C3CC44841J.
Haav, K., Kadam, S.A., Toom, L., Gale, P.A., Busschaert, N., Wenzel, M., Hiscock, J.R., Kirby, I.L., Haljasorg, T., Lõkov, M., Leito, I. Accurate method to quantify binding in supramolecular chemistry. J. Org. Chem. 78, 7796-7808 (2013). DOI: 10.1021/jo400626p.
2012
Busschaert, N., Kirby, I.L., Young, S., Coles, S.J., Horton, P.N., Light, M.E., Gale, P.A. Squaramides as potent transmembrane anion transporters. Angew. Chem. Int. Ed. 51, 4426-4430 (2012). DOI: 10.1002/anie.201200729.
2011
Busschaert, N., Wenzel, M., Light, M.E., Iglesias-Hernández, P., Pérez-Tomás, R., Gale, P.A. Structure–activity relationships in tripodal transmembrane anion transporters: the effect of fluorination. J. Am. Chem. Soc. 133, 14136-14148 (2011). DOI: 10.1021/ja205884y.
2010
Busschaert, N., Gale, P.A., Haynes, C.J.E., Light, M.E., Moore, S.J., Tong, C.C., Davis, J.T., Harrell, W.A. Jr. Tripodal transmembrane transporters for bicarbonate. Chem. Commun. 46, 6252-6254 (2010). DOI: 10.1039/C0CC01684E.
