Igor V. Rubtsov

We are developing novel methods for measuring 3D structures of molecules in solution at physiological temperatures. We are also interested in applying these new structural methods and target the mechanisms of protein and enzyme biological functioning. Three-dimensional structure arrangement and dynamics of structural fluctuations play key roles in enzymes functioning. Nonlinear femtosecond spectroscopy methods, such as two-dimensional IR spectroscopy, permits measuring quick snapshots of the structural distribution of molecules in solution.

Discipline

Multidimensional Infrared Spectroscopy, Biophysics, Ultrafast Laser Spectroscopy

Selected Publications

Alexander L. Burin, Igor V. Parshin, Igor V. Rubtsov, Maximum propagation speed and Cherenkov effect in optical phonon. J. Chem. Phys. (2023), 159, 5, 054903. DOI: 10.1063/5.0158201, https://doi.org/10.1063/5.0158201

Tammy X. Leong, Brenna K. Collins, Sourajit Dey Baksi, Robert T. Mackin, Artem Sribnyi, Alexander L. Burin, John A. Gladysz and Igor V. Rubtsov, Tracking Energy Transfer Across a Platinum Center, submitted to J. Phys. Chem. A, (2022) 126(30), 4915-4930. https://pubs.acs.org/doi/10.1021/acs.jpca.2c02017

Lev Chuntonov, Igor V. Rubtsov; Perspective: 2DIR spectroscopy for studies of molecular structure and dynamics on surfaces of noble metals. J. Phys. Chem. C. 2022, 126, 7, 3314-3327. Invited.  https://doi.org/10.1021/acs.jpcc.1c10817. Identified as the most popular article. 

I. V. Rubtsov, A. L. Burin, Ballistic and diffusive vibrational energy transport in molecules. J. Chem. Phys. Perspective; (2018) 150(2), 020901(1-18) (invited) https://doi.org/10.1063/1.5055670.

Clyde Varner, Xiao Zhou, Zowie K. Saxman, Joel D. Leger, Janarthanan Jayawickramarajah, Igor V. Rubtsov, Azido alkanes as convenient reporters for mobility within lipid membranes. Chem. Phys. (2018) 512, 20-26 (invited); https://doi.org/10.1016/j.chemphys.2018.05.020

R. T. Mackin, B. Cohn, A. Gandman, L. Chuntonov, I. V. Rubtsov, Surface-enhanced dual-frequency two-dimensional vibrational spectroscopy of thin layers at the interface; J. Phys. Chem. C (2018) 122 (20), 11015-11023, DOI: 10.1021/acs.jpcc.8b02436 https://pubs.acs.org/doi/10.1021/acs.jpcc.8b02436

Rubtsova, N. I.; Qasim, L., N.; Kurnosov, A. A.; Burin, A. L.; Rubtsov, I. V., Ballistic energy transport in oligomers. Acc. Chem. Res. (2015), 48, 2547-2555; DOI: 10.1021/acs.accounts.5b00299; http://pubs.acs.org/doi/pdfplus/10.1021/acs.accounts.5b00299.

N. I. Rubtsova, I. V. Rubtsov; Vibrational Energy Transport Studied by Relaxation Assisted 2DIR; Ann. Rev. Phys. Chem. (2015), 717-738, invited; http://www.annualreviews.org/doi/full/10.1146/annurev-physchem-040214-1…

Joel D. Leger, Clara M. Nyby, Clyde Varner, Jianan Tang, Natalia I. Rubtsova, Yuankai Yue, Victor V. Kireev, Grigory I. Rubtsov, Igor V. Rubtsov; Fully automated dual-frequency three-pulse-echo 2DIR spectrometer accessing spectral range from 800 to 4000 wavenumbers; Rev. Sci. Instr., (2014) 85, 083109-16; DOI: 10.1063/1.4892480; http://scitation.aip.org/content/aip/journal/rsi/85/8/10.1063/1.4892480.

Z. Lin, I. V. Rubtsov, Constant-speed vibrational signaling along polyethylene glycol chain up to 60-angstrom distance; Proc. Natl. Acad. Sci. U.S.A., (2012) 109(5) 1413-1418; DOI: 10.1073/pnas.1116289109.

Rubtsov, I. V.  Relaxation-assisted 2DIR: Accessing distances over 10Å and measuring bond connectivity patterns. Acc. Chem. Res. (2009), 42(9), 1385-1394; DOI: 10.1021/ar900008p.

Z. Lin, C. M. Lawrence, D. Xiao, S. S. Skourtis, J. L. Sessler, D. N. Beratan, I. V. Rubtsov, Modulating unimolecular charge transfer by exciting bridge vibrations; J. Am. Chem. Soc. (2009), 131, 18060-62; DOI: 10.1021/ja907041t; http://pubs.acs.org/doi/abs/10.1021/ja907041t?source=chemport.  The paper has been recognized in Concentrates of Chemical & Engineering News (C&EN Dec. 7, 2009, p. 41) and in Nature Chemistry, Research  Highlights, on-line at http://www.nature.com/nchem/reshigh/2009/1209/full/nchem.516.html.

Kurochkin, D. V.; Naraharisetty, S. G.; Rubtsov, I. V., Relaxation-assisted 2D IR spectroscopy method. Proc. Natl. Acad. Sci. U.S.A., (2007) 104, 14209-14214; http://www.pnas.org/content/104/36/14209