Ph.D., 2005, The Universtiy of Texas at Austin
- Tulane Cancer Center
- Tulane Vector Borne Infectious Diseases Research Center
- Tulane Lung Biology Program
- Tulane Bio-innovation Program
Research interests include Nanobiotechnology, Molecular Recognition and Self-Assembly.
Exquisitely controlled self-assembly in water is a key modality used by Nature to build highly functional biological systems. Research in the Jayawickramarajah group involves a highly interdisciplinary effort to develop bio-inspired functional molecules capable of undergoing specific molecular recognition events. A main thrust of our research is to study water compatible, self-assembling, synthetically functionalized oligomers that address contemporary problems. We are currently focused on the following two research areas.
Development of Stimuli Responsive Protein-Binders Based on DNA-Small Molecule Chimeras
This project focuses on the development of DNA-small molecule chimeras that are programmed to bind and inhibit salient protein targets only upon non-covalent activation by specific endogenous or externally introduced trigger molecules. The development of general mechanisms for the non-covalent transformation of inactive protein inhibitors into activated compounds in the presence of specific endogenous (or externally added) stimuli is envisioned to contribute to prodrug development.
Development of Well-Defined Porphyrin Arrays in Water: Towards Photonic Nanostructures
This project concerns the development of photonic nanowires composed of self-assembled multi-porphyrins in water. In these assemblies, the individual chromophores are non p-aggregated and are placed, via molecular recognition, at well-defined positions. The generation of self-assembled multi-porphyrin containing photonic nanostructures in water is envisioned to have potential applications as synthetic light harvesting antennae, catalyst arrays, and chemo-responsive sensing materials.
As a result of our prepare-and-analyze philosophy, students in the laboratory will be versed in synthetic organic chemistry and chemical biology, as well as being proficient in a whole host of spectroscopic, microscopic, and analytical techniques.
Organic and Biochemistry
Pathak, P.; Yao, W.; Hook, K. D.; Vik, R..; Winnerdy, F. R.; Brown, J. Q.; Gibb, B. C.; Pursell, Z F.; Phan, A. T.; Jayawickramarajah, J. Bright G-quadruplex nanostructures functionalized with porphyrin lanterns. J. Am. Chem. Soc. 2019, 141, 12582-12591. DOI: 10.1021/jacs.9b03250.
Qasim, L.; Atuk, E. B.; Maksymov, A.; Jayawickramarajah, J.; Burin, A.; Rubtsov, I. Ballistic transport of vibrational energy through an amide group bridging alkyl chains. J. Phys. Chem. C, 2019, 123 (6), 3381–3392. DOI: 10.1021/acs.jpcc.8b11570.
Zhou, X.; Pathak. P.; Jayawickramarajah, J. Design, synthesis, and applications of DNA-macrocyclic host Conjugates. Chem Comm. 2018, 54, 11668-11680. DOI: 10.1039/c8cc06716c.
Aryal, G.; Vik, R.; Khaleel, A.; Hunter, K.; Liming, H.; Jayawickramarajah, J.; Nau, W. Structural effects on guest binding in cucurbituril-perylene monoimide host-guest complexes. ChemistrySelect 2018, 3, 4699-4704. DOI: 10.1002/slct.201800696.
Varner, C.; Zhou, X.; Leger, J. D.; Jayawickramarajah, J.; Rubtsov, I. V. Azido alkanes as convenient reporters for mobility within lipid membranes. Chemical Physics. 2018 DOI: 10.1016/j.chemphys.2018.05.020.
Zhou, X.;Su, X.; Pathak, P.; Vik, R.; Vinciguerra, B.; Isaacs, L.; Jayawickramarajah, J. Host-Guest tethered DNA transducer: ATP fueled release of a protein inhibitor from cucurbituril. J. Am. Chem. Soc.2017, 139, 13916-13921. DOI: 10.1021/jacs.7b07977.
Aryal, G.; Battle, C. H.; Grusenmeyer, T. A.; Zhu, M.; Jayawickramarajah, J. A napthalimide derived fluorescence sensor for solid-phase screening of cucurbituril-guest interactions Chem Comm.2016, 52,2307-2310. DOI: 10.1039/C5CC08350H.
Link: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c5cc08350h - !divAbstract