Education

Ph.D., 2000, Tulane University

Biography

The broad goal of Dr. Daniel’s research is to understand mechanisms by which estrogens and androgens impact areas of the brain important for cognition. Current work in the lab is focused on the impact of these hormones on the brain and cognition across the lifespan, from early in development during which they help organize mammalian brains as male or female to later in life during which changes in their levels impact the aging brain. Research is conducted in rodent models and experimental approaches used in the lab include behavioral analyses as well as biochemical and molecular assays.

Selected Publications

Baumgartner, N.E.*, Grissom, E.M.*, Pollard, K.J., McQuillen, S.M.  & Daniel, J.M. (2019). *co-first authors. Neuroestrogen-dependent transcriptional activity in the brains of ERE-Luciferase reporter mice following short- and long-term ovariectomy. eNeuro, 6(5) ENEURO.0275-19: 1- 11.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795557/

Pollard, K.J. & Daniel, J.M. (2019). Nuclear estrogen receptor activation by insulin-like growth factor- 1 in Neuro-2A neuroblastoma cells requires endogenous estrogen synthesis and is mediated by mutually repressive MAPK and PI3K cascades. Molecular and Cellular Endocrinology, 490: 68-79.  https://www.ncbi.nlm.nih.gov/pubmed/30986444

Darling, J.S., & Daniel, J.M. (2019). Pubertal hormones mediate sex differences in levels of myelin basic protein in the orbitofrontal cortex of adult rats. Neuroscience, 406: 487-495.  https://www.ncbi.nlm.nih.gov/pubmed/30926549

Black, K.L., Baumgartner, N.E., & Daniel, J.M. (2018). Lasting impact on memory of midlife exposure to exogenous and endogenous estrogens. Behavioral Neuroscience,132: 547-551.  https://www.ncbi.nlm.nih.gov/pubmed/30160505

Pollard, K.J., Wartman, H.D., & Daniel, J.M. (2018). Previous estradiol treatment in ovariectomized mice provides lasting enhancement of memory and brain estrogen receptor activity. Hormones and Behavior, 102: 76-84.  https://www.ncbi.nlm.nih.gov/pubmed/29742445

Zimmerman, M.A., Hutson, D.D., Trimmer, E.H., Kashyap, S.N., Duong, J.L., Murphy, B., Grissom, E.M., Daniel, J.M. & Lindsey, S.H. (2017). Long- but not short-term estradiol treatment induces renal damage in midlife ovariectomized Long- Evans rats. American Journal of Physiology-Renal Physiology, 312(2): F305-F311.  https://www.ncbi.nlm.nih.gov/pubmed/28153915

Daniel, J.M., Beck, K.D. (2017) Hormones and Memory. In: Eichenbaum, H. (ed.), Memory Systems, Vol. 3 of Learning and Memory: A Comprehensive Reference, 2nd edition, Byrne, J.H. (ed.). pp. 445–462. Oxford: Academic Press. http://dx.doi.org/10.1016/B978-0-12-809324-5.21091-2

Grissom, E.M. & Daniel, J.M. (2016). Evidence for ligand-independent activation of hippocampal estrogen receptor alpha by insulin-like growth factor-1 in hippocampus of ovariectomized rats. Endocrinology, 157(8): 3149-56. https://www.ncbi.nlm.nih.gov/pubmed/27254005

Nelson, B.S., Black, K.L., & Daniel J.M. (2016). Circulating estradiol regulates brain-derived estradiol via actions at GnRH receptors to impact memory in ovariectomized rats. eNeuro, 3(6) pii: ENEURO.0321-16.2016. https://www.ncbi.nlm.nih.gov/pubmed/28032117

Black, K.L., Witty, C.F., & Daniel J.M. (2016). Previous oestradiol treatment results in long-term maintenance of hippocampal oestrogen receptor α levels in ovariectomised rats: Mechanisms and implications for memory. Journal of Neuroendocrinology, 28(10) https://www.ncbi.nlm.nih.gov/pubmed/27603028

Bayless, D.W. & Daniel, J.M. (2015). Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control. Neuroscience, 300: 286-296. https://www.ncbi.nlm.nih.gov/pubmed/26002313

Daniel, J.M., Witty, C. F., Rodgers, S. P. (2015). Long-term consequences of estrogens administered in midlife on female cognitive aging. Invited review in Special Issue, Estradiol and Cognition: Molecules to Mind, Hormones and Behavior, 74: 77-85. https://www.ncbi.nlm.nih.gov/pubmed/25917862

Bayless, D. W., Perez, M. C., Daniel, J. M. (2015). Comparison of the validity of the use of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder in males and females. Behavioural Brain Research, 286: 85-92. https://www.ncbi.nlm.nih.gov/pubmed/25724583

Nelson, B.S, Springer, R.C. & Daniel, J.M.  (2014). Antagonism of brain insulin-like growth factor-1 receptors blocks estradiol effects on memory and levels of hippocampal synaptic proteins in ovariectomized rats. Psychopharmacology, 231: 899-907. https://www.ncbi.nlm.nih.gov/pubmed/23010136

Bayless, D.W., Darling, J.S. & Daniel, J.M. (2013). Mechanisms by which neonatal testosterone exposure mediates sex differences in impulsivity in prepubertal rats. Hormones and Behavior: 64: 764-769. https://www.ncbi.nlm.nih.gov/pubmed/24126137

Daniel, J.M. (2013). Estrogens, estrogen receptors and female cognitive aging: Impact of timing. Invited review in Special Issue, Hormones & Neurotrauma, Hormones and Behavior, 63: 231-237. https://www.ncbi.nlm.nih.gov/pubmed/22587940

Witty, C.F., Gardella, L.P., Perez, M.C. & Daniel, J.M. (2013). Short-term estradiol administration in aging ovariectomized rats provides lasting benefits for memory and the hippocampus: a role for insulin-like growth factor-I. Endocrinology, 154: 842-852. https://www.ncbi.nlm.nih.gov/pubmed/23264616

Witty, C.F., Foster, T.C., Semple-Rowland, S.L. & Daniel, J.M. (2012). Increasing hippocampal estrogen receptor alpha levels via viral vectors increases MAP kinase activation and enhances memory in aging rats in the absence of ovarian estrogens. PLOS ONE, 7(12):e51385. https://www.ncbi.nlm.nih.gov/pubmed/23240018