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Research Seminars: Applied and Computational Mathematics

Spring 2021

Time & Location: Typically talks will be Friday in Zoom Chat at 3:30 PM.
Organizers: Nathan Glatt-Holtz and Kun Zhao

Archives

 

 

January 29

Title: DNA methylation-based aging biomarkers in health and disease

Mary Sehl | UCLA

Abstract: DNA methylation-based estimates of age are strongly correlated with chronologic age across many cell types and tissues. Importantly, these biologic aging estimates are accelerated in disease states, and predictive of both lifespan and healthspan. Recent evidence suggests that female breast tissue ages faster than other parts of the body in healthy women, based on the Horvath pan-tissue epigenetic clock. Estrogens are thought to contribute to breast cancer risk through cell cycling and accelerated breast aging. We hypothesize that epigenetic breast aging is driven by lifetime estrogen exposure. In this talk, we will review the development and key features of several epigenetic clocks including Horvath’s pan-tissue clock and the Hannum clock, as well as second generation clocks including the Phenotypic age, Grim age, and Skin and Blood age clocks. We will describe findings from a recent study examining associations between hormonal factors (including earlier age at menarche, and body mass index) and these epigenetic aging measures in healthy women. We will further describe additional applications of peripheral blood methylation age estimates to study biologic age acceleration in HIV-infected men pre- and post-initiation of antiretroviral therapy, and in early stage breast cancer survivors undergoing radiotherapy and chemotherapy.

 

February 5

Title: TBA

Michael Betancourt | Symplectomorphic, LLC

Abstract: TBA

 

February 12

Title: TBA

Katharina Schuh | Hausdorff Center for Mathematics, University of Bonn

Abstract: TBA

 

February 26

Title: TBA

Alfonso Landeros | UCLA

Abstract: TBA

 

March 5

Title: TBA

Nitsan Ben-Gal | 3M

Abstract: TBA

 

March 12

Title: TBA

Matt Hoffman | Google Research

Abstract: TBA

 

April 2

Title: TBA

Shiwei Lan | Arizona State University School of Mathematical and Statistical Sciences Department

Abstract: TBA

 

April 16

Title: TBA

Chia Ying Lee | Motorola Solutions

Abstract: TBA