Mathematics Home / Research Seminars: Applied and Computational Mathematics
Time & Location: Typically talks will be Friday in Zoom Chat at 3:30 PM.
Organizers: Nathan Glatt-Holtz and Kun Zhao
January 29
Title: DNA methylation-based aging biomarkers in health and disease
Mary Sehl | UCLA
Abstract: DNA methylation-based estimates of age are strongly correlated with chronologic age across many cell types and tissues. Importantly, these biologic aging estimates are accelerated in disease states, and predictive of both lifespan and healthspan. Recent evidence suggests that female breast tissue ages faster than other parts of the body in healthy women, based on the Horvath pan-tissue epigenetic clock. Estrogens are thought to contribute to breast cancer risk through cell cycling and accelerated breast aging. We hypothesize that epigenetic breast aging is driven by lifetime estrogen exposure. In this talk, we will review the development and key features of several epigenetic clocks including Horvath’s pan-tissue clock and the Hannum clock, as well as second generation clocks including the Phenotypic age, Grim age, and Skin and Blood age clocks. We will describe findings from a recent study examining associations between hormonal factors (including earlier age at menarche, and body mass index) and these epigenetic aging measures in healthy women. We will further describe additional applications of peripheral blood methylation age estimates to study biologic age acceleration in HIV-infected men pre- and post-initiation of antiretroviral therapy, and in early stage breast cancer survivors undergoing radiotherapy and chemotherapy.
February 5
Title: TBA
Michael Betancourt | Symplectomorphic, LLC
Abstract: TBA
February 12
Title: TBA
Katharina Schuh | Hausdorff Center for Mathematics, University of Bonn
Abstract: TBA
February 26
Title: TBA
Alfonso Landeros | UCLA
Abstract: TBA
March 5
Title: TBA
Nitsan Ben-Gal | 3M
Abstract: TBA
March 12
Title: TBA
Matt Hoffman | Google Research
Abstract: TBA
April 2
Title: TBA
Shiwei Lan | Arizona State University School of Mathematical and Statistical Sciences Department
Abstract: TBA
April 16
Title: TBA
Chia Ying Lee | Motorola Solutions
Abstract: TBA